pleiotropy
pleiotropy için tanımlar
Isim
1
the production by a single gene of two or more apparently unrelated effects.
These salutary effects of ezetimibe on statin levels presumably enhance the beneficial effects attributed to statin pleiotropy .
Pleiotropy örnekleri
Many semidwarf mutants have pleiotropic effects on traits other than culm length.
In this study, three factors affecting the distribution of fixed mutational effects are evaluated: pleiotropy , drift, and stabilizing selection.
Many mutants died or showed pleiotropic defects casting doubt on the specificity of their retinal phenotype and were not included in this report.
These salutary effects of ezetimibe on statin levels presumably enhance the beneficial effects attributed to statin pleiotropy .
At the level of populations, the scaling of mutational effects with pleiotropy can be addressed via the neutral theory of molecular evolution.
If gene effects on the trait and fitness are correlated due to pleiotropy , genes of large effect on the trait will remain at much lower frequencies.
Pleiotropism is a hallmark of cytokines and growth factors; yet, the underlying mechanisms are not clearly understood.
There appears to be a common logic that can be discerned behind the list of these pleiotropic changes in cell metabolism.
The gene exhibited pleiotropism by influencing not only oleate and linoleate, but also levels of palmitate, gadoleate, and total saturated fatty acids.
Conservation of this function in humans may explain many of the pleiotropic phenotypes of cartilage hair hypoplasia.
If the majority of mutations have large negative impacts on fitness, pleiotropism will act to increase their selective effects in nature.
These studies demonstrated that performance and preference of host-plant use may be genetically associated by linkage or pleiotropy , and evolve as correlated traits.
Similarly, mutations within the Drosophila CBP homolog have wide-ranging pleiotropic phenotypes.
