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Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies
Abnormalities of dopamine function in schizophrenia are suggested by the common antidopaminergic properties of antipsychotic medications. However, direct evidence of a hyperdopaminergic state in s... [Read More]
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The effect of first- and second-generation antipsychotics on brain morphology in schizophrenia: A systematic review of longitudinal magnetic resonance studies with a randomized allocation to treatment arms
Schizophrenia manifests as loss of brain volume in specific areas in a progressive nature and an important question concerns whether long-term treatment with medications contributes to this. The a... [Read More]
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Frontiers | The Benefit of Slice Timing Correction in Common fMRI Preprocessing Pipelines | Neuroscience
Due to the nature of fMRI acquisition protocols, slices cannot be acquired simultaneously, and as a result, are temporally misaligned from each other. To correct from this misalignment, preprocessing ... [Read More]
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Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: a meta-analysis
Magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of the frontal and temporal lobes in schizophrenia patients and healthy controls have proliferated over the past 2 d... [Read More]
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Motor Behavior is Relevant for Understanding Mechanism, Bolstering Prediction, And Improving Treatment: A Transdiagnostic Perspective | Schizophrenia Bulletin | Oxford Academic
The Role of The Motor Domain in Psychosis Abnormal motor behavior was long considered to be of limited value to understanding psychosis. However, research of the past decades has challenged this ... [Read More]
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Structural Brain Imaging Evidence for Multiple Pathological Processes at Different Stages of Brain Development in Schizophrenia | Schizophrenia Bulletin | Oxford Academic
Abstract The underlying neurobiology of emerging psychotic disorders is not well understood. While there is evidence from structural imaging and other studies supporting the popular notion that... [Read More]
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Structural brain correlates of cognitive function in schizophrenia: A meta-analysis
Highlights•Robust associations between brain structure and multiple cognitive domains observed.•Functional network topography provided insight into structure-cognition associations.•Highly connected r... [Read More]
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Structural brain correlates of cognitive function in schizophrenia: A meta-analysis
Robust associations between brain structure and multiple cognitive domains observed.•Functional network topography provided insight into structure-cognition associations.•Highly connected regions with... [Read More]
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Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia
Abstract Circadian rhythm abnormalities have been described mostly with respect to manic-depressive illness; little information is available concerning circadian rhythms and schi... [Read More]
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Frontiers | A Hitchhiker's Guide to Functional Magnetic Resonance Imaging | Neuroscience
Functional Magnetic Resonance Imaging (fMRI) studies have become increasingly popular both with clinicians and researchers as they are capable of providing unique insights into brain function. However... [Read More]
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Brain-derived neurotrophic factor levels and psychopathology scores in drug-naïve first-episode psychosis
Brain-derived neurotrophic factor (BDNF) is involved in the regulation of many neuronal processes, including neurogenesis. Therefore, it is thought to be closely associated with many psychopatho... [Read More]
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Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes | PNAS
Despite significant research, the biological mechanisms underlying schizophrenia are still unclear. We shed light on structural brain differences in psychosis using an approach called morphometric... [Read More]
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Update on Deep Brain Stimulation for Dyskinesia and Dystonia: A Literature Review
Deep brain stimulation (DBS) has been an established surgical treatment option for dyskinesia from Parkinson disease and for dystonia. The present article deals with the timing of surgical inter... [Read More]