Respiratory Dysrhythmias in Patients With Tardive Dyskinesia
Tardive dyskinesia (TD) is a disorder characterized by abnormal involuntary movements and associated with neuroleptic therapy. To determine whether the respiratory muscles are involved in this condition, we compared the breathing pattern of ten patients with TD with ten patients with chronic schizophrenia
receiving neuroleptic therapy without evidence of TD, and ten
age-matched normal control subjects during resting tidal breathing,
forearm pronation-supination (a maneuver designed to elicit the abnormal
movements of TD), and breathing to a set frequency. Breathing patterns
were also assessed in seven patients with TD during a progressive
incremental exercise test and an overnight polysomnogram. Patients with
TD had an irregular tidal breathing pattern, with a greater variability
in both
tidal volume
and time of the total respiratory cycle (TTOT). Both groups of patients
receiving neuroleptic therapy had a rapid shallow breathing pattern
when performing forearm pronation-supination compared with control
subjects. There were no differences between any of the subject groups
when breathing to a set frequency.

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