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Elevated C-reactive protein is associated with sensory gating deficit in schizophrenia

Sensory and cognitive impairments and
inflammatory processes are contributing factors to the pathogenesis of
schizophrenia. A previous study found that an elevated CRP level (≥ 5 mg/L)
was associated with higher cognitive impairments in schizophrenia. We
aimed to investigate the association between an elevated CRP level and
sensory impairments defined by a sensory gating deficit (abnormal P50
suppression) in 55 outpatients. Fifteen patients (27.3%) had an elevated
CRP level that was associated with higher rate of sensory gating
deficit (60% vs. 12.5%, p < 0.001). This is the first study
suggesting a relationship between sensory gating deficit and
inflammatory processes in schizophrenia.

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