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Pharmacological and nonpharmacological augmentation treatments for clozapine-resistant schizophrenia: a systematic review and network meta-analysis with normalized entropy assessment
AbstractObjectiveTo integrate all evidence derived from randomized controlled trials (RCTs) of both pharmacological and nonpharmacological augmentation interventions for clozapine-resistant schi... [Read More]
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Memantine Rescues Neurosyphilis-Related Schizophrenic-like F... : Clinical Neuropharmacology
Objectives  Neurosyphilis, an infectious neuroinflammatory disorder, could cause diverse neuropsychiatric symptoms mimicking disorders of schizophrenia and dementia... [Read More]
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Effect of long-acting injectable antipsychotics on hospitalizations and global functioning in schizophrenia: a naturalistic mirror-image study
AbstractBackground:Partial adherence to antipsychotics is the most common cause of relapses and rehospitalization in patients with schizophrenia (SZ), leading to higher health care costs and psy... [Read More]
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Therapeutic Reference Range for Aripiprazole in Schizophrenia Revised: a Systematic Review and Metaanalysis | SpringerLink
RationaleWhile one of the basic axioms of pharmacology postulates that there is a relationship between the concentration and effects of a drug, the value of measuring blood levels is questioned ... [Read More]
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Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated by MnSOD Ala-9Val Gene Polymorphism
The imbalance between pro-oxidants and antioxidants is thought to be responsible for aging and cognitive impairment in many degenerative diseases, including schizophrenia (SZ). As the first antioxidan... [Read More]
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Abnormal Information Flow in Schizophrenia Is Linked to Psychosis | Schizophrenia Bulletin | Oxford Academic
Abstract Background and HypothesisPrior research has shown that patients with schizophrenia (SZ) show disruption in brain network connectivity that is thought to underlie their cognitive and ps... [Read More]
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Are Self-disorders in Schizophrenia Expressive of a Unifying Disturbance of Subjectivity: A Factor Analytic Approach
Abstract Background and HypothesisThe idea that a disorder of the basic self is a central feature in schizophrenia has recently been corroborated in a meta-analysis and a systematic review. Man... [Read More]
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Multimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients | Schizophrenia Bulletin | Oxford Academic
Background and HypothesisAlthough the thalamus has a central role in schizophrenia pathophysiology, contributing to sensory, cognitive, and sleep alterations, the nature and dynamics of the alte... [Read More]
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Abnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia
Previous studies have suggested that an abnormality in neuronal nicotinic acetylcholine receptor expression or function may be involved in the neuropathophysiology of schizophrenia. [3H]-nicotin... [Read More]
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Facial affect recognition in first-episode psychosis is impaired but not associated with psychotic symptoms
Highlights•Impaired affect recognition (FAR) present already in first episode psychosis (FEP).•Preserved FAR of happiness found in individuals with FEP.•Individuals with FEP mainly have impaired FAR o... [Read More]
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High-frequency oscillations and the neurobiology of schizophrenia
Neural oscillations at low- and high-frequency ranges are a fundamental feature of large-scale networks. Recent evidence has indicated that schizophrenia is associated with abnormal amplitude an... [Read More]
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Evaluation of the relationship between death anxiety and clinical features of the disease and functionality in patients with schizophrenia
AimThis study aimed to examine the relationship between death anxiety in schizophrenia patients and the clinical characteristics of the disease and its functionality.MethodThe study included 5... [Read More]
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Updated perspectives on the clinical significance of negative symptoms in patients with schizophrenia
ABSTRACTIntroduction Negative symptoms in schizophrenia are associated with poor response to available treatments, poor quality of life, and functional outcome. Therefore, they represent a subst... [Read More]
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Cortical impoverishment in a stable subgroup of schizophrenia: Validation across various stages of psychosis
BackgroundCortical thinning is a well-known feature in schizophrenia. The considerable variation in the spatial distribution of thickness changes has been used to parse heterogeneity. A ‘cortica... [Read More]
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Modifiable predictors of self-reported and performance-based functioning in individuals with schizophrenia-spectrum disorders and high levels of negative symptoms
Highlights•High levels of negative symptoms in schizophrenia confer high risk for poor functioning.•In our sample of people with schizophrenia and high negative symptoms, neurocognitive ability predic... [Read More]